The romantic comedy series follows Beth and Cindy, a social media celebrity couple called "BetCin," who join an online contest called "#RelationshipGoals" and are perceived as having a perfect relationship.

Julia Sugarbaker, Mary Jo Shively, Charlene Frazier-Stillfield and Suzanne Sugarbaker are associates at their design firm, Sugarbaker and Associates. Julia is the owner and is very outspoken and strong-willed. Mary Jo is a divorced single-parent whom is just as strong-willed as Julia, but isn't as self-confident. Charlene is the naive and trusting farm girl from Poplar Bluff, Missouri. Suzanne is the self-centered ex-beauty queen whom has a number of wealthy ex-husbands.

Nagisa Aoi is a new transfer student into one of the three prestigious all-girls Catholic high schools on Astraea Hill: a school called St. Miator (the other two are St. Spica and St. Lelim (known in the anime as Le Rim, for some reason). While getting totally lost on her first day, she stumbles into a clearing with a tree, and also into a girl with long silver hair. Nagisa is immediately smitten with the girl, Shizuma Hanazono, otherwise known as the Etoile of the three schools (the most idolized girl). Shizuma, after picking up a figurine dropped by Nagisa, kisses her on the forehead, leading to Nagisa fainting. After waking up in the school's infirmary, Nagisa then meets her new roommate, Tamao Suzumi. Things, however, will be getting a lot more complicated for the new student than just that.

Yuma, a high school second-year, is enjoying every day now that she has her first boyfriend. After she asks for relationship advice from Hotaru, her beautiful long-time friend who has had many boyfriends, Hotaru teases her for her inexperience and playfully does things to her that even her boyfriend doesn't do. Yuma and Hotaru's secret relationship continues to escalate, and Yuma finds herself unable to deny how it makes her feel. This school drama tells the story of the interwoven lives of these two girls with boyfriends.

Schoolgirls discover that they have been given the ability to materialize weapons and control robotic beasts called "Children" to stop an evil organization from their plans of domination.